| 產(chǎn)品描述： | CSF1R-IN-1 is a CSF1R inhibitor with an with an IC50 of 0.5 nM |
| 靶點(diǎn)： |
IC50: 0.5 nM (CSF1R);c-Fms |
| 體內(nèi)研究： |
CSF1R-IN-1 has favorable pharmacokinetics when dosed orally to mice. It appears suitable for in vivo pharmacology testing in the appropriate preclinical tumor model to demonstrate proof of concept. |
| 參考文獻(xiàn)： |
1. Ramachandran SA, et al. Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors. Bioorg Med Chem Lett. 2017 May 15;27(10):2153-2160. |
| 溶解性： |
DMSO : 83.33 mg/mL (173.80 mM; Need ultrasonic) |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.086 ml |
10.429 ml |
20.857 ml |
| 5 mM |
0.417 ml |
2.086 ml |
4.171 ml |
| 10 mM |
0.209 ml |
1.043 ml |
2.086 ml |
| 50 mM |
0.042 ml |
0.209 ml |
0.417 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
上海工商
危險(xiǎn)品化學(xué)品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京