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MID-1

    98%

MID-1

源葉(MedMol)
S23408
312608-54-1
C12H11N3O4S
293.30
品牌 貨號 產(chǎn)品規(guī)格 價格(RMB) 庫存（上海） 北京 武漢 南京 購買數(shù)量
源葉(MedMol) S23408-1mg 98% ￥80.00元 10 - - -
源葉(MedMol) S23408-5mg 98% ￥110.00元 7 - - -
源葉(MedMol) S23408-10mg 98% ￥200.00元 7 - - -
源葉(MedMol) S23408-25mg 98% ￥400.00元 7 - - -
源葉(MedMol) S23408-100mg 98% ￥1060.00元 7 - - -
產(chǎn)品介紹 參考文獻 質(zhì)檢證書(COA) 摩爾濃度計算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake
產(chǎn)品描述： MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake
靶點： IGF-1R
體外研究： MID-1 (5 μM; 24 h) increases the IRS-1 expression level in skeletal muscle by disrupting the MG53-IRS-1 interaction.

MID-1 (10 μM; 12 h) reduces the luciferase activity in HEK 293 cell line expressing NLUC-IRS-1 and CLUC-C14A.

MID-1 (1-20 μM; 12 h) disrupts the MG53-IRS-1 interaction but not MG53-FAK interaction in HEK 293 cells.

MID-1 (0.1-10 μM; 4-24 h) abolishes MG53-induced IRS-1 ubiquitination and degradation in HEK 293 cells.

MID-1 (5-10 μM; 24 h) increases insulin signaling and insulin-elicited glucose uptake in C2C12 myotubes.

MID-1 (5-10 μM; 24 h) enhances skeletal myogenesis.
體內(nèi)研究： MID-1 does not have good pharmacokinetics in vivo.
參考文獻： 1. Lee H, et, al. MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) Interaction Disruptor Sensitizes Insulin Signaling in Skeletal Muscle. J Biol Chem. 2016 Dec 23;291(52):26627-26635.
溶解性： Soluble  in  DMSO
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 3.409 ml 17.047 ml 34.095 ml
5 mM 0.682 ml 3.409 ml 6.819 ml
10 mM 0.341 ml 1.705 ml 3.409 ml
50 mM 0.068 ml 0.341 ml 0.682 ml
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參考文獻

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摩爾濃度計算器

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