| 產(chǎn)品描述： | Porcn-IN-1 is potent porcupine inhibitor with an IC50 of 0.5±0.2 nM. |
| 靶點(diǎn)： |
IC50: 0.5±0.2 nM (Porcupine inhibitor);Porcupine |
| 體內(nèi)研究： |
Porcn-IN-1 demonstrates moderate clearance under the treatment of human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg). It exhibits high clearance when treated with mouse microsomes (109 mL/min/kg) |
| 參考文獻(xiàn)： |
1. Xu Z, et al. Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the 'reversed' amide scaffold. |
| 溶解性： |
DMSO : ≥ 100 mg/mL (243.64 mM) |
| 保存條件： |
2-8℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.436 ml |
12.182 ml |
24.364 ml |
| 5 mM |
0.487 ml |
2.436 ml |
4.873 ml |
| 10 mM |
0.244 ml |
1.218 ml |
2.436 ml |
| 50 mM |
0.049 ml |
0.244 ml |
0.487 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
上海工商
危險(xiǎn)品化學(xué)品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京