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YK-4-279

    
99%

YK-4-279

源葉(MedMol)
S80046 一鍵復(fù)制產(chǎn)品信息
1037184-44-3
C17H13Cl2NO4
366.2
YK4-279; CS-0667;
貨號(hào) 規(guī)格 價(jià)格 上海 北京 武漢 南京 購(gòu)買數(shù)量
S80046-5mg 99% ¥306.00 6 - - -
S80046-10mg 99% ¥476.00 7 - - -
S80046-25mg 99% ¥1020.00 6 - - -
S80046-50mg 99% ¥1530.00 4 - - -
S80046-100mg 99% ¥2465.00 5 - - -
S80046-200mg 99% ¥4760.00 貨期:2-3天 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used for the research of cancer

產(chǎn)品描述: YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used for the research of cancer
靶點(diǎn): IC50: 0.94 μM (TC32), 1.83 μM (TC71), 1.03 μM (RDES), 0.33 μM (SKES), 0.94 μM (MMH-ES-1), 0.60 μM (STA-ET 7.2), 1.46 μM (A4573), 4.95 μM (PC3), 22.82 μM ( MCF7), 0.82 μM (MDA-MB-231), 1.514 μM (PANC1), 14.28 μM (ASPC1);Apoptosis;DNA/RNASynthesis
體內(nèi)研究: YK-4-279 (1.5 mg; i.p. once) inhibited ESFT tumor growth
參考文獻(xiàn): 1. Erkizan HV, et al. A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma. Nat Med. 2009 Jul;15(7):750-6. 2. Barber-Rotenberg JS, et al. Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. Oncotarget. 2012 Feb;3(2):172-82.
溶解性: DMSO  :  25  mg/mL  (68.27  mM;  Need  ultrasonic)
保存條件: -20℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 2.731 ml 13.654 ml 27.307 ml
5 mM 0.546 ml 2.731 ml 5.461 ml
10 mM 0.273 ml 1.365 ml 2.731 ml
50 mM 0.055 ml 0.273 ml 0.546 ml
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參考文獻(xiàn)

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摩爾濃度計(jì)算器

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