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R428 (BGB324)

99%

R428 (BGB324)

產(chǎn)品說(shuō)明書核磁下載

品牌：源葉(MedMol)

產(chǎn)品編號(hào)：S80047

CAS號(hào)：1037624-75-1

分子式：C₃₀H₃₄N₈

分子量：506.64

別名：1H-1,2,4-Triazole-3,5-diamine, 1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5H-benzocyclohepten-2-yl]-

品牌	貨號(hào)	產(chǎn)品規(guī)格	價(jià)格(RMB)	庫(kù)存（上海）	北京	武漢	南京
源葉(MedMol)	S80047-1mg	99%	￥50.00元	7	-	-	-
源葉(MedMol)	S80047-2mg	99%	￥80.00元	4	-	-	-
源葉(MedMol)	S80047-5mg	99%	￥100.00元	8	-	-	-
源葉(MedMol)	S80047-10mg	99%	￥180.00元	6	-	-	-
源葉(MedMol)	S80047-50mg	99%	￥710.00元	6	-	-	-
源葉(MedMol)	S80047-100mg	99%	￥1290.00元	預(yù)計(jì)交期：2-3天	-	-	-

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產(chǎn)品介紹參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器相關(guān)產(chǎn)品

產(chǎn)品介紹

Bemcentinib (R428) is a potent and selective inhibitor of Axl with an IC50 of 14 nM

產(chǎn)品描述：

Bemcentinib (R428) is a potent and selective inhibitor of Axl with an IC50 of 14 nM

靶點(diǎn)：

IC50: 14 nM (Axl kinase);TAMReceptor

體內(nèi)研究：

Bemcentinib (R428) (125 mg/kg, p.o.) significantly blocks MDA-MB-231-luc-D3H2LN metastases development in two independent mouse models of breast cancer dissemination, suppresses both tumor angiogenesis and vascular endothelial growth factor (VEGF)-induced corneal neovascularization in vivo. Bemcentinib (R428) (75 mg/kg/day, 25 mg/kg twice daily, p.o.) makes mice keep on a high-fat diet resulted in significantly reduced weight gain and subcutaneous and gonadal fat mass

參考文獻(xiàn)：

1. Sensi M, et al. Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase. J Invest Dermatol. 2011 Dec;131(12):2448-57. 2. Holland SJ, et al. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res. 2010 Feb 15;70(4):1544-54. 3. Lijnen HR, et al. Growth arrest-specific protein 6 receptor antagonism impairs adipocyte differentiation and adipose tissue development in mice. J Pharmacol Exp Ther. 2011 May;337(2):457-64.

溶解性：

DMSO : 25 mg/mL (49.34 mM; ultrasonic and warming and heat to 60°C)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.974 ml	9.869 ml	19.738 ml
5 mM	0.395 ml	1.974 ml	3.948 ml
10 mM	0.197 ml	0.987 ml	1.974 ml
50 mM	0.039 ml	0.197 ml	0.395 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(COA)

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