| 產(chǎn)品描述： | Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects |
| 靶點(diǎn)： |
5-HT1A Receptor:5.74 (pKi);5-HT2A Receptor:7.54 (pKi);5-HT2C Receptor:5.55 (pKi);D2 Receptor:7.25 (pKi);5-HT1A Receptor:4.77 (pEC50);D2 Receptor:6.33 (pIC50);DopamineReceptor;5-HTReceptor;AdrenergicReceptor;AChR;HistamineReceptor |
| 體內(nèi)研究： |
Quetiapine (10?mg/kg/day; ingested) can alleviate the recruitment and activation of microglia and promote myelin repair in Cuprizone (CPZ)-induced chronic mouse model of demyelination |
| 參考文獻(xiàn)： |
1. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66. 2. Hanzhi Wang, et al. Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination. Front Cell Neurosci. 2015 Dec 21;9:492. |
| 溶解性： |
Soluble in DMSO、H2O、Ethanol |
| 保存條件： |
2-8℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.607 ml |
13.037 ml |
26.075 ml |
| 5 mM |
0.521 ml |
2.607 ml |
5.215 ml |
| 10 mM |
0.261 ml |
1.304 ml |
2.607 ml |
| 50 mM |
0.052 ml |
0.261 ml |
0.521 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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危險(xiǎn)品化學(xué)品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京