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Biapenem 98%

(4R,5S,6S)-3-((6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-yl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

源葉(MedMol)
S80161
120410-24-4
C15H18N4O4S
350.39
品牌 貨號(hào) 產(chǎn)品規(guī)格 價(jià)格(RMB) 庫存（上海） 北京 武漢 南京 購買數(shù)量
源葉(MedMol) S80161-5mg 98% ￥120.00元 >10 - - -
源葉(MedMol) S80161-10mg 98% ￥200.00元 >10 - - -
源葉(MedMol) S80161-25mg 98% ￥380.00元 >10 - - -
源葉(MedMol) S80161-50mg 98% ￥640.00元 >10 - - -
源葉(MedMol) S80161-100mg 98% ￥910.00元 >10 - - -
源葉(MedMol) S80161-200mg 98% ￥1360.00元 >10 - - -
源葉(MedMol) S80161-1g 98% ￥2800.00元 >10 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Biapenem is a 1-beta-methylcarbapenem antibiotic with a wide range of antibacterial activity. Biapenem has similar antibacterial activity to that of imipenem, but is more stable against human renal dehydropeptidase-I and with less neurotoxicity.
產(chǎn)品描述： Biapenem is a 1-beta-methylcarbapenem antibiotic with a wide range of antibacterial activity. Biapenem has similar antibacterial activity to that of imipenem, but is more stable against human renal dehydropeptidase-I and with less neurotoxicity.
靶點(diǎn)： Antibacterial;Antibiotic
體外研究：
Biapenem has activity comparable to those of Imipenem and Meropenem against all groups of anaerobes with MICs for 90% of the strains tested of 0.06 to 2 mg/mL. Biapenem is more active than ampicillin-sulbactam, ticarcillin-clavulanate, piperacillin, cefoxitin, cefotaxime, and ceftriaxone. Biapenem is also active against all of the B. capillosus, Prevotella, Clostridium, and Eubacterium strains and anaerobic cocci tested.Biapenem shows broad antibacterial activity against both Gram-positive and Gram-negative clinical isolates.Biapenem is found to be approximately as active as imipenem, inhibiting 90% of isolates of most species at concentrations within one dilution of the MIC of imipenem for 90% of the isolates.
體內(nèi)研究：
Biapenem results in significantly fewer viable bacteria than in the lungs of control mice. Biapenem prevents the progression of lung inflammation, including alveolar neutrophil infiltration and hemorrhage. Biapenem significantly prolongs survival and reduces the number of viable bacteria in a murine model of VAP caused by P. aeruginosa.
參考文獻(xiàn)：
1. Malanoski GJ, et al. In vitro activity of biapenem against clinical isolates of gram-positive and gram-negative bacteria. Antimicrob Agents Chemother, 1993, 37(9), 22009-22016. 2. Hara T, et al. [Antibacterial activity of biapenem against recent clinical isolates]. Jpn J Antibiot, 2003, 56(2), 138-141. 3. Aldridge KE, et al. In vitro activity of biapenem (L-627), a new carbapenem, against anaerobes. Antimicrob Agents Chemother, 1994, 38(4), 889-893. 4. Yamada K, et al. In vitro activity of biapenem (L-627), a new carbapenem, against anaerobes. J Infect Chemother, 2012, 18(4), 472-478.
溶解性： Soluble  in  H2O
保存條件： 2-8℃,避光
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.854 ml 14.27 ml 28.54 ml
5 mM 0.571 ml 2.854 ml 5.708 ml
10 mM 0.285 ml 1.427 ml 2.854 ml
50 mM 0.057 ml 0.285 ml 0.571 ml
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