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GDC-0349

    ≥99%

GDC-0349

源葉(MedMol)
S80169
1207360-89-1
C24H32N6O3
452.55
RG7603;Urea, N-ethyl-N'-[4-[5,6,7,8-tetrahydro-4-[(3S)-3-methyl-4-morpholinyl]-7-(3-oxetanyl)pyrido[3,4-d]pyrimidin-2-yl]phenyl]-
品牌 貨號 產(chǎn)品規(guī)格 價格(RMB) 庫存（上海） 北京 武漢 南京 購買數(shù)量
源葉(MedMol) S80169-5mg ≥99% ￥850.00元 10 - - -
源葉(MedMol) S80169-10mg ≥99% ￥1530.00元 10 - - -
源葉(MedMol) S80169-25mg ≥99% ￥3100.00元 8 - - -
源葉(MedMol) S80169-50mg ≥99% ￥4839.00元 7 - - -
源葉(MedMol) S80169-100mg ≥99% ￥7739.00元 6 - - -
產(chǎn)品介紹 參考文獻 質(zhì)檢證書(COA) 摩爾濃度計算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

GDC-0349 is a potent and selective ATP-competitive mTOR inhibitor with a Ki of 3.8 nM. GDC-0349 inhibits of both mTORC1 and mTORC2 complexes.
產(chǎn)品描述： GDC-0349 is a potent and selective ATP-competitive mTOR inhibitor with a Ki of 3.8 nM. GDC-0349 inhibits of both mTORC1 and mTORC2 complexes.
靶點： mTOR:3.8 nM (Ki);mTORC1p;mTORC2;Autophagy ;PI3K;mTOR;Autophagy
體內(nèi)研究： When dosed orally once daily in athymic mice in a MCF7-neo/Her2 tumor xenograft model (PI3K mutation), GDC-0349 (Compound 8h) inhibits tumor growth in a dose-dependent manner, achieving stasis (99% TGI) at the maximum tolerated dose. Body weight change is less than 10% up to the highest dose. GDC-0349 is also efficacious in other xenograft models, including PC3 (PTEN null) and 786-0 (VHL mutant). Similar levels of tumor growth inhibition are achieved when GDC-0349 is administered once every three days at higher doses compared to once every day. GDC-0349 has ~10-fold reduced free plasma clearance in both mice (100 mL/min/kg) and rats (171 mL/min/kg in rat)
參考文獻： 1. Pei Z, et al. Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349. ACS Med Chem Lett. 2012 Nov 29;4(1):103-7.
溶解性： Soluble  in  DMSO
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.21 ml 11.049 ml 22.097 ml
5 mM 0.442 ml 2.21 ml 4.419 ml
10 mM 0.221 ml 1.105 ml 2.21 ml
50 mM 0.044 ml 0.221 ml 0.442 ml
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參考文獻

質(zhì)檢證書(COA)

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摩爾濃度計算器

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