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StemRegenin 1 99%

StemRegenin 1

源葉(MedMol)
S80193
1227633-49-9
C24H23N5OS
429.5373
品牌 貨號(hào) 產(chǎn)品規(guī)格 價(jià)格(RMB) 庫(kù)存（上海） 北京 武漢 南京 購(gòu)買數(shù)量
源葉(MedMol) S80193-5mg 99% ￥272.00元 預(yù)計(jì)交期：2-3天 - - -
源葉(MedMol) S80193-10mg 99% ￥320.00元 3 - - -
源葉(MedMol) S80193-25mg 99% ￥720.00元 預(yù)計(jì)交期：2-3天 - - -
源葉(MedMol) S80193-50mg 99% ￥1120.00元 5 - - -
源葉(MedMol) S80193-100mg 99% ￥1920.00元 預(yù)計(jì)交期：2-3天 - - -
源葉(MedMol) S80193-200mg 99% ￥3520.00元 預(yù)計(jì)交期：2-3天 - - -
源葉(MedMol) S80193-250mg 99% ￥3840.00元 預(yù)計(jì)交期：2-3天 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor.
產(chǎn)品描述： StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor.
靶點(diǎn)： AhR;Aryl Hydrocarbon Receptor;AhR;ArylHydrocarbonReceptor
體外研究：
在NOD.Cg-Prkdcscid Il2rgtm1Wj1 / SzJ（NSG）小鼠中,通過(guò)SR1促進(jìn)CB CD34 +細(xì)胞的增殖,能夠有助于在早期進(jìn)行細(xì)胞植入及持續(xù)植入
體內(nèi)研究：
在體外,StemRegenin 1（1 μM）能夠促進(jìn)CD34 +細(xì)胞的增殖（EC 50=?120 nM）,同時(shí)降低VentX的表達(dá)水平。StemRegenin 1能夠抑制光親和配體（PAL）結(jié)合（IC 50 = 40 nM）
細(xì)胞實(shí)驗(yàn)： StemRegenin 1 (SR1) is prepared in DMSO and stored, and then diluted with appropriate medium before use. A quantity of 250,000 CB-derived CD34+ cells are cultured with control conditions (DMSO, 0.01%) or StemRegenin 1 (0.75 μM) for 3 weeks. At this point control cultures had expanded 1080-fold and StemRegenin 1 treated cells expanded 2024-fold relative to starting cell numbers. A quantity of 30 to 30,000 uncultured CD34+ CB-derived cells or a fraction of the final culture equivalent to 30 to 10,000 starting cells are transplanted. The cells are injected intravenously via the retro-orbital route into sub-lethally irradiated (300 rads, 200 rads) 6- to 10-week-old NSG mice. Engraftment is performed within 24 h after irradiation. Engraftment is monitored by flow cytometric analysis of blood obtained via retro-orbital sinus or bone marrow using anti-human CD45 and anti-mouse CD45 antibodies. The mice are sacrificed between 13-16 weeks posttransplantation; bone marrow (from both femurs and tibiae), spleen and thymu
參考文獻(xiàn)：
1. Gao H, et al. Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells. J Biol Chem, 2012, 287(35), 219979-291987. 2. Gori JL, et al. Efficient generation, purification, and expansion of CD34(+) hematopoietic progenitor cells from nonhuman primate-induced pluripotent stem cells. Blood, 2012, 120(13), e35-44. 3. Jin H, Ji C, Ren F, et al. AHR-Mediated Oxidative Stress Contributes to the Cardiac Developmental Toxicity of Trichloroethylene in Zebrafish Embryos[J]. Journal of Hazardous Materials. 2020, 385: 121521. 4. Boitano AE, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science, 2010, 329(5997), 1345-1348.
溶解性： soluble  in  DMSO
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.328 ml 11.64 ml 23.281 ml
5 mM 0.466 ml 2.328 ml 4.656 ml
10 mM 0.233 ml 1.164 ml 2.328 ml
50 mM 0.047 ml 0.233 ml 0.466 ml
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摩爾濃度計(jì)算器

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