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XMD8-87 98%

XMD8-87

源葉(MedMol)
S80208
1234480-46-6
C24H27N7O2
445.5169
品牌 貨號 產(chǎn)品規(guī)格 價格(RMB) 庫存(上海) 北京 武漢 南京 購買數(shù)量
源葉(MedMol) S80208-1mg 98% ¥240.00元 10 - - -
源葉(MedMol) S80208-2mg 98% ¥420.00元 10 - - -
源葉(MedMol) S80208-5mg 98% ¥580.00元 7 - - -
源葉(MedMol) S80208-10mg 98% ¥1100.00元 8 - - -
源葉(MedMol) S80208-25mg 98% ¥2250.00元 6 - - -
源葉(MedMol) S80208-50mg 98% ¥3700.00元 預(yù)計交期:2-3天 - - -
源葉(MedMol) S80208-100mg 98% ¥5300.00元 預(yù)計交期:2-3天 - - -
產(chǎn)品介紹 參考文獻 質(zhì)檢證書(COA) 摩爾濃度計算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively
產(chǎn)品描述: XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively
靶點: IC50: 38 nM (TNK2, D163E mutation), 113 nM (TNK2, R806Q mutation);Tyrosinase;PPAR
體外研究:
XMD8-87 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1,000 nM). XMD8-87 has IC50s of 38 nM and 113 nM for the D163E and R806Q mutations. The effects of XMD8-87 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD8-87
參考文獻:
1. Maxson JE, et al. Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis.
溶解性: soluble  in  DMSO
保存條件: -20℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 2.245 ml 11.223 ml 22.446 ml
5 mM 0.449 ml 2.245 ml 4.489 ml
10 mM 0.224 ml 1.122 ml 2.245 ml
50 mM 0.045 ml 0.224 ml 0.449 ml
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參考文獻

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摩爾濃度計算器

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