| 產(chǎn)品描述： | P 22077 is a cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor with an EC50 of 8.01 μM. P 22077 also inhibits USP47 with an EC50 of 8.74 μM. |
| 靶點： |
EC50: 8.01 μM (USP7), 8.74 μM (USP47);DUB |
| 體內(nèi)研究： |
P 22077 (15?mg/kg, i.p. 21 days) shows potent antitumor activities in an xenograft mouse model bearing IMR-32-derived tumors; P 22077 also exhibits antitumor effects after treatment at 10?mg/kg for 14 days in mice bearing SH-SY5Y-derived tumors, and at 20 mg/kg for 12 days in mice bearing NGP-derived tumors |
| 參考文獻： |
1. Altun M, et al. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chem Biol. 2011 Nov 23;18(11):1401-12. 2. Fan YH, et al. USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis. Cell Death Dis. 2013 Oct 17;4:e867. |
| 溶解性： |
DMSO : 50 mg/mL (158.57 mM; Need ultrasonic) |
| 保存條件： |
2-8℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.171 ml |
15.857 ml |
31.714 ml |
| 5 mM |
0.634 ml |
3.171 ml |
6.343 ml |
| 10 mM |
0.317 ml |
1.586 ml |
3.171 ml |
| 50 mM |
0.063 ml |
0.317 ml |
0.634 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京