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Verteporfin

    97%(HPLC)

Verteporfin

源葉(MedMol)
S80258
129497-78-5
C41H42N4O8
718.79
維替泊芬;微替泊芬;維替鉑芬;VERTEPORFIN (200 MG);trans-3,4-Dicarboxy-4,4a-dihydro-4a,8,14,19-tetramethyl-18-vinyl-23H,25H-benzo(b)porphine-9,13-dipropionic acid 3,4,9-trimethyl ester;Verteporfin;Verteporphin;Verte
品牌 貨號 產(chǎn)品規(guī)格 價格(RMB) 庫存（上海） 北京 武漢 南京 購買數(shù)量
源葉(MedMol) S80258-1mg 97%(HPLC) ￥102.00元 3 - - -
源葉(MedMol) S80258-5mg 97%(HPLC) ￥391.00元 5 - - -
源葉(MedMol) S80258-10mg 97%(HPLC) ￥720.00元 3 - - -
源葉(MedMol) S80258-25mg 97%(HPLC) ￥1275.00元 6 - - -
源葉(MedMol) S80258-50mg 97%(HPLC) ￥2295.00元 5 - - -
源葉(MedMol) S80258-100mg 97%(HPLC) ￥3910.00元 5 - - -
產(chǎn)品介紹 參考文獻(1篇) 質(zhì)檢證書(COA) 摩爾濃度計算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis. Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation
產(chǎn)品描述： Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis. Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation
靶點： IC50: YAP-TEAD interaction;Apoptosis;YAP;VDA;Autophagy
體內(nèi)研究： Verteporfin (10 mg/kg, c.s.c.) and BMS-354825 significantly reduces the leukemia cell ratio, and combined therapy further reduced the number of leukemia cells in the spleen
參考文獻： 1. Morishita T, et al. The photosensitizer verteporfin has light-independent anti-leukemic activity for Ph-positive acute lymphoblastic leukemia and synergistically works with BMS-354825. Oncotarget. 2016 Aug 2. 2. Pan W, et al. Verteporfin can Reverse the NSC 125973 Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression. Cell Physiol Biochem. 2016;39(2):481-90. 3. Donohue E, et al. The autophagy inhibitor verteporfin moderately enhances the antitumor activity of gemcitabine in a pancreatic ductal adenocarcinoma model.J Cancer. 2013 Aug 28;4(7):585-96.
溶解性： DMF  :  10  mg/mL  (13.91  mM;  ultrasonic  and  warming  and  heat  to  60°C)
保存條件： -20℃，充氮保存
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 1.391 ml 6.956 ml 13.912 ml
5 mM 0.278 ml 1.391 ml 2.782 ml
10 mM 0.139 ml 0.696 ml 1.391 ml
50 mM 0.028 ml 0.139 ml 0.278 ml
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摩爾濃度計算器

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