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Bindarit

    
98%

Bindarit

源葉(MedMol)
S80266 一鍵復制產品信息
130641-38-2
C19H20N2O3
324.374
賓達利;2-[(1-benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid; Bindarit; Bindarit (USAN/INN); 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid;
貨號 規(guī)格 價格 上海 北京 武漢 南京 購買數量
S80266-5mg 98% ¥400.00 7 - - -
S80266-10mg 98% ¥680.00 9 - - -
S80266-50mg 98% ¥1976.00 8 - - -
S80266-100mg 98% ¥3200.00 3 - - -
產品介紹 參考文獻 質檢證書(COA) 摩爾濃度計算器 相關產品

產品介紹

Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23. Bindarit also has anti-inflammatory activity

產品描述: Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23. Bindarit also has anti-inflammatory activity
靶點: MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8;CCR
體內研究: Bindarit (50 mg/kg; oral administration; every day; for 4 months, 6 months, 8 months; NZB/W F1 female mice) delays the onset of proteinuria and significantly protects from renal function impairment. Bindarit completely prevents monocyte chemoattractant protein (MCP-1) up-regulation
參考文獻: 1. Grassia, G., et al., The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice. Cardiovasc Res, 2009. 84(3): p. 485-93. 2. Zoja C, Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease. Kidney Int. 1998 Mar;53(3):726-34.
溶解性: DMSO  :  ≥  46  mg/mL  (141.81  mM)
保存條件: 2-8℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 3.083 ml 15.414 ml 30.829 ml
5 mM 0.617 ml 3.083 ml 6.166 ml
10 mM 0.308 ml 1.541 ml 3.083 ml
50 mM 0.062 ml 0.308 ml 0.617 ml
注意: 部分產品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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