| 產(chǎn)品描述： | ETP-46464 is an effective mTOR and ATR inhibitor with IC50s of 0.6 and 14 nM, respectively. |
| 靶點： |
mTOR:0.6 nM (IC50);ATR:14 nM (IC50);ATM:545 nM (IC50);DNA-PK:36 nM (IC50);PI3Kα:170 nM (IC50);ATM/ATR;DNA-PK;PI3K;mTOR |
| 參考文獻(xiàn)： |
1. Toledo LI, et al. A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat Struct Mol Biol. 2011 Jun;18(6):721-7. 2. Teng PN, et al. Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells. Gynecol Oncol. 2015 Mar;136(3):554-61. |
| 溶解性： |
DMSO : 5 mg/mL (10.63 mM; Need ultrasonic) |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.125 ml |
10.627 ml |
21.253 ml |
| 5 mM |
0.425 ml |
2.125 ml |
4.251 ml |
| 10 mM |
0.213 ml |
1.063 ml |
2.125 ml |
| 50 mM |
0.043 ml |
0.213 ml |
0.425 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學(xué)品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京