| 產(chǎn)品描述： | K02288 is a potent bone morphogenetic protein (BMP) type I receptor inhibitor with IC50s of 1.8, 1.1, 6.4 nM for ALK1, ALK2 and ALK6, respectively. K02288 shows slightly weaker inhibition against ALK3 and ALK6 with IC50s of of 5-34 nM. |
| 靶點(diǎn)： |
IC50：1.8 nM (ALK1), 1.1 nM (ALK2), 34.4 nM (ALK3), 6.3 nM (ALK6), 302 nM (ALK4), 321 nM (ALK5);ALK;TGF-beta/Smad |
| 體內(nèi)研究： |
K02288 (1 μM) induces dysfunctional angiogenesis in a chick embryo CAM model |
| 參考文獻(xiàn)： |
1. Sanvitale CE, et al. A new class of small molecule inhibitor of BMP signaling. PLoS One. 2013 Apr 30;8(4):e62721. 2. Kerr G, et al. A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis. Angiogenesis. 2015 Apr;18(2):209-17. |
| 溶解性： |
DMSO : ≥ 58.6 mg/mL (166.30 mM) |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.838 ml |
14.189 ml |
28.378 ml |
| 5 mM |
0.568 ml |
2.838 ml |
5.676 ml |
| 10 mM |
0.284 ml |
1.419 ml |
2.838 ml |
| 50 mM |
0.057 ml |
0.284 ml |
0.568 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶(hù)參考交流研究之用。 |
上海工商
危險(xiǎn)品化學(xué)品經(jīng)營(yíng)許可證（不帶存儲(chǔ)）
營(yíng)業(yè)執(zhí)照(三證合一)
北京