| 產(chǎn)品描述： | SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM. |
| 靶點： |
VEGFR3：23 nM (IC50);VEGFR |
| 體內(nèi)研究： |
SAR131675 is very well tolerated in mice and shows a potent antitumoral effect in several orthotopic and syngenic models, including mammary 4T1 carcinoma and RIP1.Tag2 tumors. Interestingly, it significantly reduces lymph node invasion and lung metastasis, showing its antilymphangiogenic activity in vivo. SAR131675 significantly reduces TAM infiltration and aggregation in 4T1 tumors |
| 參考文獻： |
1. Alam A, et al. SAR131675, a potent and selective VEGFR-3-TK inhibitor with antilymphangiogenic, antitumoral, and antimetastatic activities. Mol Cancer Ther. 2012 Aug;11(8):1637-49. |
| 溶解性： |
DMSO : 100 mg/mL (279.03 mM; ultrasonic and warming and heat to 60°C) |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.79 ml |
13.951 ml |
27.903 ml |
| 5 mM |
0.558 ml |
2.79 ml |
5.581 ml |
| 10 mM |
0.279 ml |
1.395 ml |
2.79 ml |
| 50 mM |
0.056 ml |
0.279 ml |
0.558 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京