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SAQUINAVIR MESYLATE

    99%

SAQUINAVIR MESYLATE

源葉(MedMol)
S80386
149845-06-7
C39H54N6O8S
766.946
沙奎拉韋;甲磺酸沙奎拉韋;沙奎拉韋甲磺酸鹽;RO 31-8959;SAQUINAVIR MESYLATE;INVIRASE;FORTOVASE;(2S)-N1[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-Dimethylethyl)amino]carbonyl]octahydro-2-(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)
品牌 貨號(hào) 產(chǎn)品規(guī)格 價(jià)格(RMB) 庫(kù)存(上海) 北京 武漢 南京 購(gòu)買數(shù)量
源葉(MedMol) S80386-10mg 99% ¥300.00元 6 - - -
源葉(MedMol) S80386-50mg 99% ¥800.00元 6 - - -
源葉(MedMol) S80386-250mg 99% ¥1800.00元 預(yù)計(jì)交期:2-3天 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(shū)(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Saquinavir mesylate is an HIV Protease Inhibitor used in antiretroviral therapy. IC50 Value: Target: HIV Protease Saquinavir is a protease inhibitor. Proteases are enzymes that cleave protein molecules into smaller fragments. HIV protease is vital for both viral replication within the cell and release of mature viral particles from an infected cell. Saquinavir binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus. Saquinavir inhibits both HIV-1 and HIV-2 proteases.Studies have also looked at Saquinavir as a possible anti-cancer agent.
產(chǎn)品描述: Saquinavir mesylate is an HIV Protease Inhibitor used in antiretroviral therapy. IC50 Value: Target: HIV Protease Saquinavir is a protease inhibitor. Proteases are enzymes that cleave protein molecules into smaller fragments. HIV protease is vital for both viral replication within the cell and release of mature viral particles from an infected cell. Saquinavir binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus. Saquinavir inhibits both HIV-1 and HIV-2 proteases.Studies have also looked at Saquinavir as a possible anti-cancer agent.
靶點(diǎn): HIV-1;HIV-2;HIVProtease;Autophagy
參考文獻(xiàn): 1. Kaldor et al (1995) Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease. Bioorg.Med.Chem.Lett. 5 721. 2. Yerino GA, Halabe EK, Zini E, Feleder EC. Bioequivalence study of two oral tablet formulations containing saquinavir mesylate boosted with ritonavir in healthy male subjects. Arzneimittelforschung. 2011;61(8):481-7. 3. Branham ML, Moyo T, Govender T. Preparation and solid-state characterization of ball milled saquinavir mesylate for solubility enhancement. Eur J Pharm Biopharm. 2012 Jan;80(1):194-202. 4. Brouwers J, Vermeire K, Grammen C, Schols D, Augustijns P. Early identification of availability issues for poorly water-soluble microbicide candidates in biorelevant media: a case study with saquinavir. Antiviral Res. 2011 Aug;91(2):217-23. 5. Knechten H, Lutz T, Pulik P, Martin T, Tappe A, Jaeger H. Safety and Efficacy in HIV-1-Infected Patients Treated with Ritonavir-Boosted Saquinavir Mesylate.
溶解性: DMSO  :  20  mg/mL  (26.08  mM;  Need  ultrasonic)
保存條件: 2-8℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 1.304 ml 6.519 ml 13.039 ml
5 mM 0.261 ml 1.304 ml 2.608 ml
10 mM 0.13 ml 0.652 ml 1.304 ml
50 mM 0.026 ml 0.13 ml 0.261 ml
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參考文獻(xiàn)

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摩爾濃度計(jì)算器

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