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Lopinavir 99%

Lopinavir

源葉(MedMol)
S80504
192725-17-0
C37H48N4O5
628.8
品牌 貨號(hào) 產(chǎn)品規(guī)格 價(jià)格(RMB) 庫(kù)存（上海） 北京 武漢 南京 購(gòu)買數(shù)量
源葉(MedMol) S80504-10mg 99% ￥40.00元 3 - - -
源葉(MedMol) S80504-50mg 99% ￥120.00元 7 - - -
源葉(MedMol) S80504-100mg 99% ￥200.00元 6 - - -
源葉(MedMol) S80504-250mg 99% ￥320.00元 4 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivit. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM
產(chǎn)品描述： Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivit. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM
靶點(diǎn)： HIV;HIV Protease;SARS-CoV;SARS-CoV;HIVProtease
體內(nèi)研究：
Coadministration with low-dose Ritonavir significantly improves the pharmacokinetic properties and hence the activity of Lopinavir against HIV-1 protease
參考文獻(xiàn)：
1. Cvetkovic RS, et al. Lopinavir/ritonavir: a review of its use in the management of HIV infection. Drugs. 2003;63(8):769-802. 2. Sham HL, et al. ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease. Antimicrob Agents Chemother. 1998;42(12):3218-3224. 3. Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.
溶解性： DMSO  :  250  mg/mL  (397.58  mM;  Need  ultrasonic)
保存條件： 2-8℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 1.59 ml 7.952 ml 15.903 ml
5 mM 0.318 ml 1.59 ml 3.181 ml
10 mM 0.159 ml 0.795 ml 1.59 ml
50 mM 0.032 ml 0.159 ml 0.318 ml
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參考文獻(xiàn)

質(zhì)檢證書(COA)

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摩爾濃度計(jì)算器

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