| 產(chǎn)品描述： | Gemifloxacin mesylate (SB-265805S; LB-20304a) is an orally active broad-spectrum quinolone antibacterial antibiotic. Gemifloxacin mesylate inhibits DNA synthesis by inhibiting DNA gyrase and Topoisomerase IV activities. Gemifloxacin mesylate has potent antibacterial activities against gram-positive bacteria in vitro efficacy study, particularly Streptococci and Staphylococci. Gemifloxacin mesylate has been used in the research of respiratory tract infections |
| 靶點： |
Antibiotic, Bacterial, DNA synthesis, Topoisomerase IV;DNAgyrase;Topoisomerase;Antibacterial |
| 體內(nèi)研究： |
Gemifloxacin has favorable pharmacokinetic profile in animals after oral administration |
| 參考文獻： |
1. Hong CY. Discovery of gemifloxacin (Factive, LB20304a): a quinolone of a new generation. Farmaco. 2001 Jan-Feb;56(1-2):41-4. 2. Allen A, Kim I, et al. Multiple-dose pharmacokinetics and tolerability of gemifloxacin administered orally to healthy volunteers. Antimicrob Agents Chemother. 2001 Feb;45(2):540-5. 3. Erdem M, et al. Ingestion of the anti-bacterial agent, gemifloxacin mesylate, leads to increased gst activity and peroxidation products in hemolymph of Galleria mellonella l. (lepidoptera: pyralidae). Arch Insect Biochem Physiol. 2016 Dec;93(4):202-209. |
| 溶解性： |
DMSO : 100 mg/mL (205.98 mM; Need ultrasonic) H2O : 50 mg/mL (102.99 mM; Need ultrasonic) |
| 保存條件： |
2-8℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.06 ml |
10.299 ml |
20.598 ml |
| 5 mM |
0.412 ml |
2.06 ml |
4.12 ml |
| 10 mM |
0.206 ml |
1.03 ml |
2.06 ml |
| 50 mM |
0.041 ml |
0.206 ml |
0.412 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京