| 產(chǎn)品描述： | Molsidomine is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO) upon decay as the actual vasodilating compound. |
| 靶點(diǎn)： |
NOD |
| 體內(nèi)研究： |
Molsidomine (50, 100, 250 μg/kg) reduces coronary flow while the coronary resistance remains unaffected by molsidomine. Molsidomine decreases myocardial oxygen consumption. Heart rate and contractility remains unchanged by molsidomine. Stroke volume and cardiac output fall after molsidomine. The fall in blood pressure after molsidomine follows the reduction in cardiac output as sequel of lowered preload and venous return to the heart |
| 參考文獻(xiàn)： |
1.Volker B. Fiedler, et al. Naunyn-Schmiedeberg's Archives of Pharmacology. 1981, 317(1):71-77. |
| 溶解性： |
Ethanol:21 mg/mL(86.7 mM) DMSO:45 mg/mL (185.8 mM) H2O:9 mg/mL (37.15 mM) |
| 保存條件： |
2-8°C,避光 |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
4.128 ml |
20.642 ml |
41.283 ml |
| 5 mM |
0.826 ml |
4.128 ml |
8.257 ml |
| 10 mM |
0.413 ml |
2.064 ml |
4.128 ml |
| 50 mM |
0.083 ml |
0.413 ml |
0.826 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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