| 產(chǎn)品描述： | CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM |
| 靶點(diǎn)： |
Aryl Hydrocarbon Receptor;AhR;ArylHydrocarbonReceptor |
| 體內(nèi)研究： |
CH-223191 (10 mg/kg; once a day; 25 days) suppresses cytochrome P450 1A1 expression and the intrahepatocyte fat content in liver, reduces activity of AST and ALT in TCDD-treated mice |
| 參考文獻(xiàn)： |
1. Kim SH, et al. Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol. 2006 Jun;69(6):1871-8. Epub 2006 Mar |
| 溶解性： |
DMSO : 62.5 mg/mL (187.47 mM; ultrasonic and warming and heat to 60°C) |
| 保存條件： |
2-8℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.999 ml |
14.997 ml |
29.995 ml |
| 5 mM |
0.6 ml |
2.999 ml |
5.999 ml |
| 10 mM |
0.3 ml |
1.5 ml |
2.999 ml |
| 50 mM |
0.06 ml |
0.3 ml |
0.6 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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