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YM201636

    98%

YM201636

源葉(MedMol)
S80688
371942-69-7
C25H21N7O3
467.48
3-Pyridinecarboxamide, 6-amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-
品牌 貨號(hào) 產(chǎn)品規(guī)格 價(jià)格(RMB) 庫(kù)存（上海） 北京 武漢 南京 購(gòu)買數(shù)量
源葉(MedMol) S80688-1mg 98% ￥216.00元 1 - - -
源葉(MedMol) S80688-2mg 98% ￥352.00元 4 - - -
源葉(MedMol) S80688-5mg 98% ￥720.00元 4 - - -
源葉(MedMol) S80688-10mg 98% ￥960.00元 6 - - -
源葉(MedMol) S80688-25mg 98% ￥1920.00元 預(yù)計(jì)交期：2-3天 - - -
源葉(MedMol) S80688-50mg 98% ￥3600.00元 預(yù)計(jì)交期：2-3天 - - -
源葉(MedMol) S80688-100mg 98% ￥5600.00元 預(yù)計(jì)交期：2-3天 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

YM-201636 is a potent and selective PIKfyve inhibitor with an IC50 of 33 nM. YM-201636 also inhibits p110α with an IC50 of 3.3 μM. YM-201636 inhibits retroviral replication.
產(chǎn)品描述： YM-201636 is a potent and selective PIKfyve inhibitor with an IC50 of 33 nM. YM-201636 also inhibits p110α with an IC50 of 3.3 μM. YM-201636 inhibits retroviral replication.
靶點(diǎn)： PIKfyve:33 nM (IC50);p110α:3.3 μM (IC50);Autophagy ;InfluenzaVirus;PI3K;Autophagy
參考文獻(xiàn)： 1. Jefferies HB, et al. A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding. EMBO Rep, 2008, 9(2), 164-170. 2. Ikonomov OC, et al. YM-201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes. Biochem Biophys Res Commun. 2009 May 8;382(3):566-70. 3. Sbrissa D, et al. Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM-201636. Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C436-46. 4. Dukes JD, et al. The PIKfyve inhibitor YM-201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. PLoS One. 2012;7(3):e28659. 5. Ikonomov OC, et al. YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes. Biochem Biophys Res Commun. 2009 May 8;382(3):566-70.
溶解性： DMSO  :  ≥  47  mg/mL  (100.54  mM)
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.139 ml 10.696 ml 21.391 ml
5 mM 0.428 ml 2.139 ml 4.278 ml
10 mM 0.214 ml 1.07 ml 2.139 ml
50 mM 0.043 ml 0.214 ml 0.428 ml
注意： 部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(COA)

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摩爾濃度計(jì)算器

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