| 產(chǎn)品描述： | Dacinostat is a potent HDAC inhibitor, with an IC50 of 32 nM; Dacinostat also inhibits HDAC1 with an IC50 of 9 nM, and used in cancer research. |
| 靶點： |
HDAC1:9 nM (IC50);HDAC:32 nM (IC50);HDAC;Autophagy |
| 體內(nèi)研究： |
NVP-LAQ824 produces a dose-dependent inhibition of tumor growth, and at 100 mg/kg, its antitumor effect is similar to that of 5-Fluorouracil |
| 參考文獻(xiàn)： |
1. Atadja P, et al. Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824. Cancer Res. 2004 Jan 15;64(2):689-95. 2. Cho YS, et al. Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824). J Med Chem. 2010 Apr 8;53(7):2952-63. 3. Romanski A, et al. Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells. Cell Cycle. 2012 Sep 1;11(17):3219-26. |
| 溶解性： |
DMSO : ≥ 43 mg/mL (113.32 mM) |
| 保存條件： |
2-8℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.635 ml |
13.177 ml |
26.354 ml |
| 5 mM |
0.527 ml |
2.635 ml |
5.271 ml |
| 10 mM |
0.264 ml |
1.318 ml |
2.635 ml |
| 50 mM |
0.053 ml |
0.264 ml |
0.527 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學(xué)品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京