| 產(chǎn)品描述： | GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway. |
| 靶點： |
Gli1/2;Hedgehog/Smoothened;Autophagy |
| 體內(nèi)研究： |
GANT-61 (40 mg/kg, i.p., three days per week) inhibits CSC tumor growth in NOD/SCID IL2Rγ null mice. GANT61 (50 mg/kg, p.o.) enhances the effects of chemotherapeutic drugs used in the treatment of neuroblastoma in an additive or synergistic manner and reduces the growth of established neuroblastoma xenografts in nude mice |
| 參考文獻： |
1. Mazumdar T, et al. Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res. 2011 Feb 1;71(3):1092-102. 2. Fu J, et al. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. 2013 Mar 1;330(1):22-32. 3. Wickstrom M, et al. Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo. Int J Cancer. 2013 Apr 1;132(7):1516-24. |
| 溶解性： |
Ethanol : 66.67 mg/mL (155.19 mM; Need ultrasonic) DMSO : 25 mg/mL (58.19 mM; Need ultrasonic) |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.328 ml |
11.639 ml |
23.277 ml |
| 5 mM |
0.466 ml |
2.328 ml |
4.655 ml |
| 10 mM |
0.233 ml |
1.164 ml |
2.328 ml |
| 50 mM |
0.047 ml |
0.233 ml |
0.466 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京