| 產(chǎn)品描述： | STO-609 is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC50 ~0.02 g/ml. |
| 靶點： |
Ki: 80 ng/mL (CaM-KKα), 15 ng/mL (CaM-KKβ);CaMK;AMPK;Autophagy |
| 參考文獻： |
1. Tokumitsu H, et al. STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem. 2002 May 3;277(18):15813-8. 2. Kukimoto-Niino M, et al. Crystal structure of the Ca2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J Biol Chem. 2011 Jun 24;286(25):22570-9. |
| 溶解性： |
DMSO : 6.25 mg/mL (19.89 mM; ultrasonic and warming and heat to 80°C) DMF : 5.56 mg/mL (17.69 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) |
| 保存條件： |
2-8℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.182 ml |
15.909 ml |
31.818 ml |
| 5 mM |
0.636 ml |
3.182 ml |
6.364 ml |
| 10 mM |
0.318 ml |
1.591 ml |
3.182 ml |
| 50 mM |
0.064 ml |
0.318 ml |
0.636 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京