| 產(chǎn)品描述： | BMS-707035 is a potent orally active HIV-1 integrase strand transfer inhibitor (INSTI). BMS-707035 has enzyme inhibitory with an IC50 value of 3 nM. BMS-707035 also has weak CYP inhibiton and antiviral activity. BMS-707035 can be used for the research of human immunodeficiency virus-1 (HIV-1) |
| 靶點： |
HIV;HIV Integrase;HIVProtease |
| 體內(nèi)研究： |
BMS-707035 has a low clearance effect in the rat, dog and monkey with moderate to long elimination half-lives in all species |
| 參考文獻： |
1. B Narasimhulu Naidu, et al. The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor. Bioorg Med Chem Lett. 2018 Jul 1;28(12):2124-2130. |
| 溶解性： |
DMSO : 50 mg/mL (121.83 mM; Need ultrasonic) |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.437 ml |
12.183 ml |
24.365 ml |
| 5 mM |
0.487 ml |
2.437 ml |
4.873 ml |
| 10 mM |
0.244 ml |
1.218 ml |
2.437 ml |
| 50 mM |
0.049 ml |
0.244 ml |
0.487 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學(xué)品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京