Levoleucovorin Calcium (Calcium levofolinate), a levo isoform of Leucovorin Calcium (HY-13664), possesses antineoplastic effects. Levoleucovorin Calcium is also an augmentor of 5-fluorouracil (HY-90006) cytotoxicity against cancer
產(chǎn)品描述:
Levoleucovorin Calcium (Calcium levofolinate), a levo isoform of Leucovorin Calcium (HY-13664), possesses antineoplastic effects. Levoleucovorin Calcium is also an augmentor of 5-fluorouracil (HY-90006) cytotoxicity against cancer
靶點(diǎn):
Antifolate
體內(nèi)研究:
Levoleucovorin Calcium (6, 20 or 60 mg/kg/day; i.v.; for 4 weeks) enhances the toxicity of 5-Fluorouracil
參考文獻(xiàn):
1. National Center for Biotechnology Information. PubChem Compound Summary for CID 135500522, Levoleucovorin calcium. 2. Murakami Y, et al. Effects of levofolinate calcium on subacute intravenous toxicity of 5-fluorouracil in rats. J Toxicol Sci. 1998 May;23 Suppl 1:11-29.
溶解性:
H2O : 10 mg/mL (19.55 mM; Need ultrasonic) DMSO : < 1 mg/mL (insoluble or slightly soluble)