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SCH772984

    98%

SCH772984

源葉(MedMol)
S81143
942183-80-4
C33H33N9O2
587.67
3-Pyrrolidinecarboxamide, 1-[2-oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-(3-phenyl-1H-indazol-5-yl)-, (3R)-
品牌 貨號(hào) 產(chǎn)品規(guī)格 價(jià)格(RMB) 庫(kù)存（上海） 北京 武漢 南京 購(gòu)買數(shù)量
源葉(MedMol) S81143-2mg 98% ￥408.00元 預(yù)計(jì)交期：2-3天 - - -
源葉(MedMol) S81143-5mg 98% ￥598.40元 1 - - -
源葉(MedMol) S81143-10mg 98% ￥1020.00元 7 - - -
源葉(MedMol) S81143-25mg 98% ￥2040.00元 6 - - -
源葉(MedMol) S81143-50mg 98% ￥3400.00元 預(yù)計(jì)交期：2-3天 - - -
源葉(MedMol) S81143-100mg 98% ￥5440.00元 預(yù)計(jì)交期：2-3天 - - -
源葉(MedMol) S81143-200mg 98% ￥7800.00元 預(yù)計(jì)交期：2-3天 - - -
產(chǎn)品介紹 參考文獻(xiàn)(1篇) 質(zhì)檢證書(shū)(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

SCH772984 is a highly selective and ATP-competitive ERK inhibitor, with IC50s of 4 and 1 nM for ERK1 and ERK2, respectively. SCH772984 has antitumor activity in MAPK inhibitor-naïve and MAPK inhibitor-resistant cells containing BRAF or RAS mutations

產(chǎn)品描述：

SCH772984 is a highly selective and ATP-competitive ERK inhibitor, with IC50s of 4 and 1 nM for ERK1 and ERK2, respectively. SCH772984 has antitumor activity in MAPK inhibitor-naïve and MAPK inhibitor-resistant cells containing BRAF or RAS mutations
靶點(diǎn)： ERK2：1 nM (IC50)；ERK1：4 nM (IC50);ERK;?MEK
體內(nèi)研究： SCH772984 (12.5-50 mg/kg; i.p.; twice daily for 14 days) leads to 98% tumor regression. Dose-dependent antitumor activity is also observed in the KRAS-mutant pancreatic MiaPaCa model, with 36% regression at 50 mg/kg twice daily. Importantly, tumor regression is accompanied by robust inhibition of ERK phosphorylation in tumor tissue. SCH772984 is well tolerated on this schedule as measured by morbidity, lethality, or body weight loss。
參考文獻(xiàn)： 1. Morris EJ, et al. Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov. 2013 Jul;3(7):742-50.
溶解性： DMSO  :  48  mg/mL  (81.68  mM;  Need  ultrasonic)
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 1.702 ml 8.508 ml 17.016 ml
5 mM 0.34 ml 1.702 ml 3.403 ml
10 mM 0.17 ml 0.851 ml 1.702 ml
50 mM 0.034 ml 0.17 ml 0.34 ml
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質(zhì)檢證書(shū)(COA)

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摩爾濃度計(jì)算器

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