| 產(chǎn)品描述： | GNE0877 is a highly selective, orally active and brain-penetrant LRRK2 inhibitor with an IC50 of 3 nM and a Ki of 0.7 nM. GNE0877 can be used for the research of neuroscience |
| 靶點(diǎn)： |
IC50: 3 nM (LRRK2);LRRK2 |
| 體內(nèi)研究： |
GNE0877 (10 and 50 mg/kg; i.p. once) inhibits LRRK2 Ser1292 autophosphorylation |
| 參考文獻(xiàn)： |
1. Estrada AA, et al. Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2014 Feb 13;57(3):921-36. |
| 溶解性： |
DMSO : 250 mg/mL (736.77 mM; Need ultrasonic) |
| 保存條件： |
2-8℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.947 ml |
14.735 ml |
29.471 ml |
| 5 mM |
0.589 ml |
2.947 ml |
5.894 ml |
| 10 mM |
0.295 ml |
1.474 ml |
2.947 ml |
| 50 mM |
0.059 ml |
0.295 ml |
0.589 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
上海工商
危險(xiǎn)品化學(xué)品經(jīng)營(yíng)許可證（不帶存儲(chǔ)）
營(yíng)業(yè)執(zhí)照(三證合一)
北京