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Acalabrutinib(ACP-196)

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Acalabrutinib(ACP-196)

源葉(MedMol)
S81320
1420477-60-6
C26H23N7O2
465.507
ACP196.Acalabrutinib; Acalabrutinib(ACP196); ACP-196; (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide; Acalabrutinib; Acalabrutinib (ACP-196); ac
品牌 貨號(hào) 產(chǎn)品規(guī)格 價(jià)格(RMB) 庫(kù)存（上海） 北京 武漢 南京 購(gòu)買數(shù)量
源葉(MedMol) S81320-1mg 98% ￥184.00元 >10 - - -
源葉(MedMol) S81320-2mg 98% ￥280.00元 >10 - - -
源葉(MedMol) S81320-5mg 98% ￥395.00元 >10 - - -
源葉(MedMol) S81320-10mg 98% ￥650.00元 >10 - - -
源葉(MedMol) S81320-50mg 98% ￥1980.00元 >10 - - -
源葉(MedMol) S81320-100mg 98% ￥3100.00元 >10 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL)[1]

產(chǎn)品描述：

Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL)[1]
靶點(diǎn)： IC50: 3 nM (BTK in CD69 B cell);BTK
體內(nèi)研究： Acalabrutinib (100 mg twice per day) assessed for thrombus formation at injured arterioles of the mice, exhibits more selective for inhibiting BTK and has virtually no inhibition of platelet activity
參考文獻(xiàn)： 1. Wu J, et al. Acalabrutinib (ACP-196): a selective second-generation BTK inhibitor. J Hematol Oncol. 2016 Mar 9;9:21 2. Herman SE, et al. The Bruton's tyrosine kinase (BTK) inhibitor acalabrutinib demonstrates potent on-target effects and efficacy in two mouse models of chronic lymphocytic leukemia. Clin Cancer Res. 2016 Nov 30
溶解性： Soluble  in  DMSO
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.148 ml 10.741 ml 21.482 ml
5 mM 0.43 ml 2.148 ml 4.296 ml
10 mM 0.215 ml 1.074 ml 2.148 ml
50 mM 0.043 ml 0.215 ml 0.43 ml
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參考文獻(xiàn)

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