| 產品描述： | Sevelamer hydrochloride is an orally active and phosphate binding agent used for research of hyperphosphatemia with chronic kidney disease. Sevelamer hydrochloride consists of polyallylamine that is crosslinked with epichlorohydrin |
| 靶點： |
FXR;Autophagy;FXR;?Autophagy |
| 體內研究： |
Sevelamer hydrochloride (1% mixed in diet; p.o.; once daily for 5 weeks) reduces Npt2b-deficient mice serum phosphate levels, but fails to reduce the level in uremic WT mice.Sevelamer hydrochloride leads to a significant decrease in osteoclast number in uremic WT mice with a trend toward further decrease in Npt2b-/- mice.Sevelamer hydrochloride leads to a significant increase in Npt2b protein expression |
| 參考文獻： |
1. Sevelamer, From Wikipedia 2. Bennis Y, et al. The Effect of Sevelamer on Serum Levels of Gut-Derived Uremic Toxins: Results from In Vitro Experiments and A Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Toxins (Basel). 2019 May 17;11(5):279. 3. Susan C Schiavi, et al. Npt2b deletion attenuates hyperphosphatemia associated with CKD. J Am Soc Nephrol. 2012 Oct;23(10):1691-700. |
| 保存條件： |
2-8℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
6.684 ml |
33.418 ml |
66.836 ml |
| 5 mM |
1.337 ml |
6.684 ml |
13.367 ml |
| 10 mM |
0.668 ml |
3.342 ml |
6.684 ml |
| 50 mM |
0.134 ml |
0.668 ml |
1.337 ml |
|
| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
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北京