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SGC707

    98%

SGC707

源葉(MedMol)
S81389
1687736-54-4
C16H18N4O2
298.3397
品牌 貨號 產(chǎn)品規(guī)格 價(jià)格(RMB) 庫存(上海) 北京 武漢 南京 購買數(shù)量
源葉(MedMol) S81389-2mg 98% ¥120.00元 5 - - -
源葉(MedMol) S81389-5mg 98% ¥240.00元 6 - - -
源葉(MedMol) S81389-10mg 98% ¥390.00元 5 - - -
源葉(MedMol) S81389-25mg 98% ¥800.00元 6 - - -
源葉(MedMol) S81389-50mg 98% ¥1350.00元 預(yù)計(jì)交期:2-3天 - - -
源葉(MedMol) S81389-100mg 98% ¥2000.00元 預(yù)計(jì)交期:2-3天 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

SGC707 is a potent, selective, and non-competitive PRMT3 (protein arginine methyltransferase 3) inhibitor (IC50=31 nM, Kd=53 nM).
產(chǎn)品描述: SGC707 is a potent, selective, and non-competitive PRMT3 (protein arginine methyltransferase 3) inhibitor (IC50=31 nM, Kd=53 nM).
靶點(diǎn): PRMT3:31 nM (IC50);HistoneMethyltransferase
體外研究: SGC707 (0-10 μM; 6 h) binds to PRMT3 in both HEK293 and A549 cells. Cell Viability Assay Cell Line: HEK293 and A549 cells Concentration: 0-10 μM Incubation Time: 6 hours Result: Stabilized PRMT3 in both HEK293 and A549 cells with EC50 values of 1.3 μM and 1.6 μM, respectively.
體內(nèi)研究: SGC707 (intraperitoneal injection; 10 mg/kg; 3 times per week; 3 w) treatment reduces hepatic steatosis and plasma triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice. Animal Model: Western-type diet-fed LDL (lipoprotein) receptor knockout mice Dosage: 10 mg/kg Administration: Intraperitoneal injection; 10 mg/kg; 3 times per week; 3 weeks Result: Exhibited 50% lower liver triglyceride stores as well as 32% lower plasma triglyceride levels.
參考文獻(xiàn): 1. Kaniskan Hü, et al. A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70. 2. de Jong LM, et al. PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice. Sci Rep. 2022 Jan 10;12(1):483.
溶解性: soluble  in  DMSO
保存條件: -20℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 3.352 ml 16.759 ml 33.519 ml
5 mM 0.67 ml 3.352 ml 6.704 ml
10 mM 0.335 ml 1.676 ml 3.352 ml
50 mM 0.067 ml 0.335 ml 0.67 ml
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參考文獻(xiàn)

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