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AMD 3465 98%

AMD 3465

源葉(MedMol)
S81410
185991-07-5
C24H44Br6N6
896.07
品牌 貨號(hào) 產(chǎn)品規(guī)格 價(jià)格(RMB) 庫存（上海） 北京 武漢 南京 購買數(shù)量
源葉(MedMol) S81410-5mg 98% ￥270.00元 6 - - -
源葉(MedMol) S81410-10mg 98% ￥400.00元 6 - - -
源葉(MedMol) S81410-50mg 98% ￥1060.00元 3 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.
產(chǎn)品描述： AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.
靶點(diǎn)： 12G5 mAb-CXCR4:0.75 nM (IC50, in SupT1 cells);CXCL12AF647-CXCR4:18 nM (IC50, in SupT1 cells);X4 HIV-1 (NL4.3):6.1 nM (IC50, in MT-4 cells);X4 HIV-1 (RF):7.4 nM (IC50, in MT-4 cells);X4 HIV-1 (HE):9.8 nM (IC50, in MT-4 cells);X4 HIV-1 (IIIB):12.3 nM (IC50, in MT-4 cells);X4 HIV-1 (NL4.3AMD3100):2822 nM (IC50, in MT-4 cells);HIV-2 (ROD):12.3 nM (IC50, in MT-4 cells);HIV-2 (EHO):12.3 nM (IC50, in MT-4 cells);HIVProtease
體內(nèi)研究：
AMD 3465 (2.5 mg/kg/d, s.c. for 5 weeks) significantly blocks the growth of U87 GBM and Daoy xenografts
參考文獻(xiàn)：
1. Hatse S, et al. AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. Biochem Pharmacol. 2005 Sep 1;70(5):752-61. 2. Yang L, et al. Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res. 2007 Jan 15;67(2):651-8.
溶解性： DMSO  :  50  mg/mL  (55.80  mM;  Need  ultrasonic)    H2O  :  ≥  38  mg/mL  (42.41  mM)
保存條件： 2-8℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 1.116 ml 5.58 ml 11.16 ml
5 mM 0.223 ml 1.116 ml 2.232 ml
10 mM 0.112 ml 0.558 ml 1.116 ml
50 mM 0.022 ml 0.112 ml 0.223 ml
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