| 產(chǎn)品描述： | APS-2-79 hydrochloride is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling |
| 靶點(diǎn)： |
KSR2:120 nM (IC50);MEK1;MEK;?MAPK |
| 體外研究： |
APS-2-79 (5 μM) suppresses KSR-stimulated MEK and ERK phosphorylation in 293H cells. APS-2-79 (1 μM) enhances the efficacy of the clinical MEK inhibitor trametinib within cancer cell lines containing K-Ras mutations |
| 參考文獻(xiàn)： |
1. Dhawan NS, et al. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature. 2016 Sep 1;537(7618):112-116. |
| 溶解性： |
DMSO |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.359 ml |
11.795 ml |
23.591 ml |
| 5 mM |
0.472 ml |
2.359 ml |
4.718 ml |
| 10 mM |
0.236 ml |
1.18 ml |
2.359 ml |
| 50 mM |
0.047 ml |
0.236 ml |
0.472 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶(hù)參考交流研究之用。 |
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營(yíng)業(yè)執(zhí)照(三證合一)
北京