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Diazoxide

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Diazoxide

源葉(MedMol)
S81465
364-98-7
C8H7ClN2O2S
230.67
氯甲苯噻嗪;7-氯-3-甲基-2氫-1,2,4-苯并噻二嗪1,1-二氧化物;二氮嗪;降壓嗪;氯甲苯噻嗪;7-氯-3-甲基-2H-1,2,4-苯并噻二嗪 1,1-二氧化物;2h-1,2,4-Benzothiadiazine,7-Chloro-3-Methyl-,1,1-Dioxide;7-Chloro-3-Methyl-2H-1,2,4-Benzothiadiazine1;7-Cloro-3-Met
品牌 貨號 產(chǎn)品規(guī)格 價(jià)格(RMB) 庫存（上海） 北京 武漢 南京 購買數(shù)量
源葉(MedMol) S81465-100mg 99% ￥102.00元 8 - - -
源葉(MedMol) S81465-250mg 99% ￥124.00元 7 - - -
源葉(MedMol) S81465-1g 99% ￥355.00元 3 - - -
源葉(MedMol) S81465-5g 99% ￥1240.00元 1 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Diazoxide is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
產(chǎn)品描述： Diazoxide is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
靶點(diǎn)： ATPase;Autophagy;Potassium Channel;ATPase;?PotassiumChannel;?Autophagy
體內(nèi)研究： Diazoxide is beneficial on the improvement in cognitive tasks, reduction of anxiety, decrease in the accumulation of amyloid-beta oligomers and hyperphosphorylation of tau proteins. Diazoxide may also exerts neuroprotective effects independently of K+ channel activation by decreasing neuronal excitability and activation of N-methyl-D-aspartate (NMDA) receptors or by increasing currents trough α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Diazoxide-treated animals show a decrease in disease severity a few days after the first clinical signs are observed, corresponding to the acute inflammatory phase of the disease. Daily oral administration of diazoxide in EAE mice during the effector phase of the disease reduces the severity of the clinical signs without any apparent adverse effect. Diazoxide decreases demyelination and axonal loss, reduces tissue damage, inhibits microglial/macrophage and astrocytic activation and preserves neuron integrity. No effects are observed on the number of B and T lymphocytes infiltrating the spinal cord
細(xì)胞實(shí)驗(yàn)： The phagocytic ability of microglia is determined by the uptake of 2-μm red fluorescent microspheres by BV-2 cells. Cells are treated with diazoxide 100 μM and activated with LPS/IFN-γ and then incubated with microspheres at a concentration of 0.01% for 30 min in the dark at 37°C and 5% CO2. Cells are rinsed twice in PBS solution, pelleted at 1,000 g for 5 min and resuspended in 300 μL PBS. Cells are kept on ice and analyzed by flow cytometry.(Only for Reference)
參考文獻(xiàn)： 1.Garlid KD, et al. Circ Res. 1997, 81(6):1072-1082. 2.Virgili N, et al. J Neuroinflammation. 2011, 8:149.
溶解性： H2O:<1  mg/mL    DMSO:43  mg/mL  (186.4  mM)    Ethanol:<1  mg/mL
保存條件： RT
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 4.335 ml 21.676 ml 43.352 ml
5 mM 0.867 ml 4.335 ml 8.67 ml
10 mM 0.434 ml 2.168 ml 4.335 ml
50 mM 0.087 ml 0.434 ml 0.867 ml
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