| 產(chǎn)品描述： | Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity |
| 靶點： |
Human Endogenous Metabolite;Others;?Antifolate |
| 體內(nèi)研究： |
Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice) |
| 參考文獻： |
1. Keshava C, et al. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res. 1998 Feb 2;397(2):221-8. 2. Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44. |
| 溶解性： |
H2O : 10 mg/mL (16.62 mM; Need ultrasonic) DMSO : 1 mg/mL (1.66 mM; ultrasonic and warming and heat to 80°C) |
| 保存條件： |
2-8℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.955 ml |
9.775 ml |
19.55 ml |
| 5 mM |
0.391 ml |
1.955 ml |
3.91 ml |
| 10 mM |
0.196 ml |
0.978 ml |
1.955 ml |
| 50 mM |
0.039 ml |
0.196 ml |
0.391 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
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北京