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YS-49 98%

YS-49

源葉(MedMol)
S82848
132836-42-1
C20H20BrNO2
404.3
品牌 貨號 產(chǎn)品規(guī)格 價格(RMB) 庫存（上海） 北京 武漢 南京 購買數(shù)量
源葉(MedMol) S82848-10mg 98% ￥850.00元 6 - - -
源葉(MedMol) S82848-50mg 98% ￥2600.00元 3 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors
產(chǎn)品描述： YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors
靶點： Akt;PI3K;Angiotensin Receptor;Adrenergic Receptor;RAAS;?Akt;?PI3K;?AdrenergicReceptor
體內(nèi)研究：
YS-49 (5?mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM
參考文獻(xiàn)：
1. Sun JJ, Kim HJ, Seo HG, et al. YS49,1-(alpha-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygen 2. Kang YJ, et al. Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages. Br J Pharmacol. 1999 Sep;128(2):357-64. 3. Hsu YH, et al. RhoA-mediated inhibition of vascular endothelial cell mobility: positive feedback through reduced cytosolic p21 and p27. J Cell Physiol. 2014 Oct;229(10):1455-65.
溶解性： DMSO  :  100  mg/mL  (258.88  mM;  Need  ultrasonic)    H2O  :  10  mg/mL  (25.89  mM;  ultrasonic  and  warming  and  heat  to  60°C)
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.473 ml 12.367 ml 24.734 ml
5 mM 0.495 ml 2.473 ml 4.947 ml
10 mM 0.247 ml 1.237 ml 2.473 ml
50 mM 0.049 ml 0.247 ml 0.495 ml
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