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T807 95%

T807

源葉(MedMol)
S83175
1415379-56-4
C16H10FN3
263.2691032
品牌 貨號 產(chǎn)品規(guī)格 價格(RMB) 庫存（上海） 北京 武漢 南京 購買數(shù)量
源葉(MedMol) S83175-1mg 95% ￥280.00元 5 - - -
源葉(MedMol) S83175-5mg 95% ￥650.00元 6 - - -
源葉(MedMol) S83175-10mg 95% ￥1120.00元 6 - - -
源葉(MedMol) S83175-50mg 95% ￥2700.00元 3 - - -
源葉(MedMol) S83175-100mg 95% ￥4100.00元 預(yù)計交期：2-3天 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

T807 a novel tau positron emission tomography (PET) tracer.
產(chǎn)品描述： T807 a novel tau positron emission tomography (PET) tracer.
靶點： Tau Protein;MicrotubuleAssociated
體外研究：
Aggregated tau protein is a major neuropathological substrate central to the pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD). In vitro autoradiography results show that [18F]T807 exhibits strong binding to PHF-tau positive human brain sections (Kd=14.6 nM). A comparison of autoradiography and double immunohistochemical staining of PHF-tau and Ab on adjacent sections demonstrates that [18F]T807 binding colocalizes with immunoreactive PHF-tau pathology, but does not highlight Ab plaques. [18F]T807 strongly binds to tau lesions primarily made of paired helical filaments in Alzheimer’s brains e.g. intra and extraneuronal tangles and dystrophic neurites. [18F]T807 off-target binding to neuromelanin- and melanin-containing cells and, to a lesser extent, to brain hemorrhagic lesions is identified
體內(nèi)研究：
[18F]T807 is able to cross the blood–brain barrier and ished out quickly in mice model. [18F]T807 clears rapidly from the brain, with activity values decreasing from 4.43% ID/g at 5 minutes to 0.62% ID/g at 30 minutes. Kidney elimination is a significant clearance pathway, resulting in a maximum tracer concentration of 14.99% ID/g in the kidneys at 5 minutes, which decreases to 5.52% ID/g at 30 minutes. The accumulation of activity in muscle and bone remain relatively low throughout the PET scan
參考文獻(xiàn)：
1. Xia CF, et al. [(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease. Alzheimers Dement. 2013 Nov;9(6):666-76. 2. Marquié M, et al. Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Ann Neurol. 2015 Nov;78(5):787-800.
溶解性： soluble  in  DMSO
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 3.798 ml 18.992 ml 37.984 ml
5 mM 0.76 ml 3.798 ml 7.597 ml
10 mM 0.38 ml 1.899 ml 3.798 ml
50 mM 0.076 ml 0.38 ml 0.76 ml
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參考文獻(xiàn)

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摩爾濃度計算器

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