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6-FORMYLINDOLO [3,2-B] CARBAZOLE

95%

6-FORMYLINDOLO [3,2-B] CARBAZOLE

產(chǎn)品說(shuō)明書(shū)

品牌：源葉(MedMol)

產(chǎn)品編號(hào)：S83917 一鍵復(fù)制產(chǎn)品信息

CAS號(hào)：172922-91-7

分子式：C₁₉H₁₂N₂O

分子量：284.31

別名：6-甲?；胚岵3,2-B]咔唑;吲哚并[3,2-B]咔唑-6-甲醛;6-FORMYLINDOLO [3,2-B] CARBAZOLE;Indolo[3,2-b]carbazole-6-carbaldehyde;5,11-dihydroindolo[3,2-b]carbazole-6-carbaldehyde;FICZ

貨號(hào)	產(chǎn)品規(guī)格	價(jià)格(RMB)	庫(kù)存（上海）	北京	武漢	南京
S83917-1mg	95%	￥550.00元	1	-	-	-
S83917-5mg	95%	￥1400.00元	5	-	-	-
S83917-10mg	95%	￥2100.00元	3	-	-	-
S83917-25mg	95%	￥3500.00元	5	-	-	-
S83917-50mg	95%	￥6500.00元	5	-	-	-

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產(chǎn)品介紹參考文獻(xiàn)(1篇) 質(zhì)檢證書(shū)(COA) 摩爾濃度計(jì)算器相關(guān)產(chǎn)品

產(chǎn)品介紹

FICZ (6-Formylindolo[3,2-b]carbazole) 是一種 aryl hydrocarbon receptor (AhR) 的有效激動(dòng)劑，可被AHR調(diào)節(jié)的細(xì)胞色素P4501酶有效地代謝

產(chǎn)品描述：

FICZ (6-Formylindolo[3,2-b]carbazole) 是一種 aryl hydrocarbon receptor (AhR) 的有效激動(dòng)劑，可被AHR調(diào)節(jié)的細(xì)胞色素P4501酶有效地代謝

靶點(diǎn)：

AhR;ArylHydrocarbonReceptor

體內(nèi)研究：

FICZ improves the atopic dermatitis-like skin inflammation, clinical scores, and transepidermal water loss in NC/Nga mice compared with those of control mice. On histology, FICZ significantly reduces the epidermal and dermal thickness as well as the number of mast cells. Topical FICZ also significantly reduces the gene expression of Il22.

細(xì)胞實(shí)驗(yàn)：

Cell lines: Human immortalized HaCaT cells, normal human epidermal keratinocytes (NHEKs) Concentrations: 1 nM, 10 nM, 100 nM Incubation Time: 1 h, 3 h, 5 h Method: HaCaTcells or NHEKs (1×104 cells/well) are platedon an 8-well μ-slide for 48 h, and treated with or without FICZ for 3 or 1 h, respectively. Then, the cells are washed with phosphate-buffered saline (PBS), fixed with acetone for 10 min, and blocked with 5% (w/v) bovine serum albumin in PBS for 30 min. The cells are then incubated with primary rabbit anti-AHR antibody (1:100) overnight at 4 ℃. Specific binding is detected using a horseradish peroxidase-conjugated goat anti-rabbit anti-body followed by tyramide labeling with green-fluorescent Alexa Fluor 488 for 1 h at room temperature in accordance with the manufacturer's instructions.

動(dòng)物實(shí)驗(yàn)：

Animal Models: 9–10 week-old female NC/Nga mice Dosages: 100 mg/affected area Administration: Topical

參考文獻(xiàn)：

1. Emma Wincent, et al. Biochem Pharmacol. 2016 Jun 15;110-111:117-29. 2. Mari Kiyomatsu-Oda, et al. J Dermatol Sci. 2018 Jun;90(3):284-294.

溶解性：

Soluble in DMSO

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.517 ml	17.586 ml	35.173 ml
5 mM	0.703 ml	3.517 ml	7.035 ml
10 mM	0.352 ml	1.759 ml	3.517 ml
50 mM	0.07 ml	0.352 ml	0.703 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶(hù)參考交流研究之用。

參考文獻(xiàn)(1篇)

1. [IF=6.2] Meiqing Li et al."Epigallocatechin-3-gallate mitigates cadmium-induced intestinal damage through modulation of the microbiota-tryptophan-aryl hydrocarbon receptor pathway."ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.2024 Jul;280:116520

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