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Tetrahydrobiopterin

98%

Tetrahydrobiopterin

產(chǎn)品說明書

品牌：源葉(MedMol)

產(chǎn)品編號：S83956

CAS號：17528-72-2

分子式：C₉H₁₅N₅O₃

分子量：241.25

別名：四氫生物喋呤;5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1h)-pteridinon;5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1h)-pteridinone;bh4;TETRAHYDRO-L-BIOPTERIN, DIHYDROCHLORIDE;THB, 2HCL;6R

品牌	貨號	產(chǎn)品規(guī)格	價格(RMB)	庫存（上海）	北京	武漢	南京
源葉(MedMol)	S83956-5mg	98%	￥1100.00元	5	-	-	-
源葉(MedMol)	S83956-10mg	98%	￥1900.00元	7	-	-	-
源葉(MedMol)	S83956-50mg	98%	￥6700.00元	6	-	-	-

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產(chǎn)品介紹參考文獻(3篇) 質(zhì)檢證書(COA) 摩爾濃度計算器相關(guān)產(chǎn)品

產(chǎn)品介紹

Tetrahydrobiopterin ((Rac)-Sapropterin) is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms.

產(chǎn)品描述：

Tetrahydrobiopterin ((Rac)-Sapropterin) is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms.

靶點：

Human Endogenous Metabolite;NOS;?EndogenousMetabolite

體內(nèi)研究：

To assess the levels of Tetrahydrobiopterin in the retina, three to five pools of retinas are collected from WT and hph-1mice at postnatal age 7, 14, and 22 and evaluated by LC-MS/MS. LC-MS/MS analysis confirm a significant decrease by approximately 90% in the concentration levels of Tetrahydrobiopterin in retinal tissue from hph-1 mice (0.0009±0.0006; p<0.0001, 0.01±0.001; p<0.0001 and 2.45±0.40; p<0.005) compare to the WT group (0.014±0.001, 0.092±0.01, and 23.13±6.44) at P7, P14, and P22, respectively

參考文獻：

1. Rivera JC, et al. Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina. J Neuroinflammation. 2017 Sep 6;14(1):181.

溶解性：

DMSO : 50 mg/mL (207.25 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	4.145 ml	20.725 ml	41.451 ml
5 mM	0.829 ml	4.145 ml	8.29 ml
10 mM	0.415 ml	2.073 ml	4.145 ml
50 mM	0.083 ml	0.415 ml	0.829 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(3篇)

3. [IF=14.9] Li Chunyan et al."Structure-based characterization and compound identification of the wild-type THF class-II riboswitch."NUCLEIC ACIDS RESEARCH".2024 May;: 2. [IF=5] Xiaoling Jiang et al."Mechanisms underlying the efficacy and limitation of dopa and tetrahydrobiopterin therapies for the deficiency of GTP cyclohydrolase 1 revealed in a novel mouse model."EUROPEAN JOURNAL OF PHARMACOLOGY".2024 Feb;:176379 1. [IF=5.81] Yan Tao et al."Ligustilide Prevents Radiation Enteritis by Targeting Gch1/BH4/eNOS to Improve Intestinal Ischemia."Front Pharmacol. 2021 Apr;0:893

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