| 產(chǎn)品描述： | UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM. |
| 靶點(diǎn)： |
Ki: 10 nM (uPA);PAI-1;?SerineProtease |
| 體外研究： |
UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 μM). UK-371804 has its excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin) |
| 體內(nèi)研究： |
In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM |
| 參考文獻(xiàn)： |
1. Fish PV, et al. Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007 May 17;50(10):2341-51. |
| 溶解性： |
Soluble in DMSO |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.592 ml |
12.959 ml |
25.918 ml |
| 5 mM |
0.518 ml |
2.592 ml |
5.184 ml |
| 10 mM |
0.259 ml |
1.296 ml |
2.592 ml |
| 50 mM |
0.052 ml |
0.259 ml |
0.518 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學(xué)品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京