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Disitertide

98%

Disitertide

產(chǎn)品說明書

品牌：源葉(MedMol)

產(chǎn)品編號(hào)：S84722

CAS號(hào)：272105-42-7

分子式：C₆₈H₁₀₉N₁₇O₂₂S₂

分子量：1580.82

別名：地司特泰;L-蘇氨酰-L-絲氨酰-L-亮氨酰-L-ALPHA-天冬氨酰-L-丙氨酰-L-絲氨酰-L-異亮氨酰-L-異亮氨酰-L-色氨酰-L-丙氨酰-L-蛋氨酰-L-蛋氨酰-L-谷氨酰胺酰-L-天冬酰胺;disitertide;L-Threonyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L

品牌	貨號(hào)	產(chǎn)品規(guī)格	價(jià)格(RMB)	庫(kù)存（上海）	北京	武漢	南京
源葉(MedMol)	S84722-1mg	98%	￥1100.00元	預(yù)計(jì)交期：2-3天	-	-	-
源葉(MedMol)	S84722-5mg	98%	￥4400.00元	預(yù)計(jì)交期：2-3天	-	-	-
源葉(MedMol)	S84722-10mg	98%	￥7500.00元	預(yù)計(jì)交期：2-3天	-	-	-

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產(chǎn)品介紹參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器相關(guān)產(chǎn)品

產(chǎn)品介紹

Disitertide (P144) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) is also a PI3K inhibitor and an apoptosis inducer

產(chǎn)品描述：

靶點(diǎn)：

TGF-beta/Smad;PI3K;Apoptosis;TGF-beta/Smad

體內(nèi)研究：

Disitertide (Topical application, 300 μg/mL) may promote scar maturation and improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment Animal Model: Human hypertrophic scars were implanted in 60 nude mice. Dosage: 300 μg/mL was added the Lipogel. Administration: Topical application daily administered. Result: Successful shedding was achieved in 83,3% of the xenografts.

參考文獻(xiàn)：

1. Cindy Neuzillet, et al. Targeting the TGFβ pathway for cancer therapy. Pharmacol Ther. 2015 Mar;147:22-31. 2. Jun Yang, et al. Upregulation of microRNA?590 in rheumatoid arthritis promotes apoptosis of bone cells through transforming growth factor?β1/phosphoinositide 3?kinase/Akt signaling. Int J Mol Med. 2019 May;43(5):2212-2220. 3. Wanming He, et al. MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer. Oncogene. 2019 Jun;38(23):4637-4654. 4. Shan Shan Qiu, et al. Effect of P144? (Anti-TGF-β) in an In Vivo Human Hypertrophic Scar Model in Nude Mice. PLoS One. 2015 Dec 31;10(12):e0144489. 5. Gabriel Gallo-Oller, et al. P144, a Transforming Growth Factor beta inhibitor peptide, generates antitumoral effects and modifies SMAD7 and SKI levels in human glioblastoma cell lines. Cancer Lett. 2016 Oct 10;381(1):67-75.

溶解性：

Soluble in H2O

保存條件：

-20°C

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	0.633 ml	3.163 ml	6.326 ml
5 mM	0.127 ml	0.633 ml	1.265 ml
10 mM	0.063 ml	0.316 ml	0.633 ml
50 mM	0.013 ml	0.063 ml	0.127 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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摩爾濃度計(jì)算器

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