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(R) Fesoterodine

95%

(R) Fesoterodine

品牌：源葉(MedMol)

產(chǎn)品編號(hào)：S84764

CAS號(hào)：286930-02-7

分子式：C₂₆H₃₇NO₃

分子量：411.58

別名：弗斯特羅定;富馬酸弗斯特羅定雜質(zhì);(R) Fesoterodine;Propanoic Acid 2-Methyl- 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl Ester;2-Methylpropanoic acid 2-[(1R)-3-[bis(1-methylethyl)amino]-

品牌	貨號(hào)	產(chǎn)品規(guī)格	價(jià)格(RMB)	庫(kù)存（上海）	北京	武漢	南京	購(gòu)買數(shù)量
源葉(MedMol)	S84764-100mg	95%	￥2400.00元	預(yù)計(jì)交期：2-3天	-	-	-
源葉(MedMol)	S84764-1g	95%	￥11000.00元	預(yù)計(jì)交期：2-3天	-	-	-

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產(chǎn)品介紹

Fesoterodine is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine is used for the overactive bladder (OAB)

產(chǎn)品描述：

靶點(diǎn)：

pKi: 8.0 (M1), 7.7 (M2), 7.4 (M3), 7.3 (M4) and 7.5 (M5);AChR

體內(nèi)研究：

Fesoterodine (0.01-1 mg/kg; IV) reduces the micturition pressure and increases bladder capacity and ICIs (intercontraction intervas) at the lowest dose tested of 0.01 mg/kg Animal Model: Bladders from female Sprague-Dawley rats (225-275 g)[3] Dosage: 0.01, 0.1 and 1 mg/kg Administration: IV Result: Reduced the micturition pressure and increased bladder capacity and ICIs at the lowest dose tested of 0.01 mg/kg.

參考文獻(xiàn)：

1. Ellsworth P, et al. Fesoterodine for the treatment of urinary incontinence and overactive bladder. Ther Clin Risk Manag. 2009;5:869-76. Epub 2009 Nov 18. 2. Didem Yilmaz-Oral, et al. The Beneficial Effect of Fesoterodine, a Competitive Muscarinic Receptor Antagonist on Erectile Dysfunction in Streptozotocin-induced Diabetic Rats 3. Peter Ney, et al. Pharmacological Characterization of a Novel Investigational Antimuscarinic Drug, Fesoterodine, in Vitro and in Vivo. BJU Int. 2008 Apr;101(8):1036-42. 4. Martin C Michel, et al. Fesoterodine: A Novel Muscarinic Receptor Antagonist for the Treatment of Overactive Bladder Syndrome. Expert Opin Pharmacother. 2008 Jul;9(10):1787-96.

溶解性：

Soluble in Ethanol

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.43 ml	12.148 ml	24.297 ml
5 mM	0.486 ml	2.43 ml	4.859 ml
10 mM	0.243 ml	1.215 ml	2.43 ml
50 mM	0.049 ml	0.243 ml	0.486 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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