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Ebselen

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Ebselen

源葉(MedMol)
S85955
60940-34-3
C13H9NOSe
274.18
MFCD00210937
依布硒;依布硒啉;2-苯基苯并異硒唑3-酮;依布硒, 依布硒啉;2-Phenyl-2-BenzIsoselenazol-3(2h)-One;PZ51;2-Phenyl-Benzo[d]Isoselenazol-3-One;2-Phenyl-1,2-Benzisoselenazol-3(2H)-One;Ebselen;Ebselen (PZ51, 2-Phenyl-1,2-Benzisoselen
品牌 貨號 產(chǎn)品規(guī)格 價格(RMB) 庫存（上海） 北京 武漢 南京 購買數(shù)量
源葉(MedMol) S85955-5mg 99% ￥300.00元 4 - - -
源葉(MedMol) S85955-10mg 99% ￥500.00元 5 - - -
源葉(MedMol) S85955-50mg 99% ￥1300.00元 6 - - -
源葉(MedMol) S85955-100mg 99% ￥2000.00元 5 - - -
產(chǎn)品介紹 參考文獻 質(zhì)檢證書(COA) 摩爾濃度計算器 相關產(chǎn)品

產(chǎn)品介紹

Ebselen (SPI-1005), a?glutathione peroxidase?mimetic, is a potent?voltage-dependent?calcium channel?(VDCC)?blocker. Ebselen potently inhibits?Mpro?(IC50=0.67 μM) and?COVID-19?virus (EC50=4.67 μM).Ebselen is an inhibitor of?HIV-1?capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity
產(chǎn)品描述： Ebselen (SPI-1005), a?glutathione peroxidase?mimetic, is a potent?voltage-dependent?calcium channel?(VDCC)?blocker. Ebselen potently inhibits?Mpro?(IC50=0.67 μM) and?COVID-19?virus (EC50=4.67 μM).Ebselen is an inhibitor of?HIV-1?capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity
靶點： IC50: 0.67 μM (Mpro) EC50: 4.67 μM (COVID-19 virus);Phosphatase;VirusProtease;CalciumChannel;COX;HIVProtease
體外研究： Ebselen (SPI-1005; 0.4-100 μM; 20-24 hours) shows strong antiviral effects at a concentration of 10 μM treatment in COVID-19 virus infected Vero cells. Ebsele covalently binds to C145 of the catalytic dyad in COVID-19 virus Mpro. Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process. Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. Ebselen inhibits inositol monophosphatase (IMPase). Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic, renal cancer cell lines. RT-PCR Cell Line: COVID-19 virus infected Vero cells Concentration: 0.4, 1.2, 3.7, 11.1, 33.3, 100 μM Incubation Time: 20-24 hours Result: Showed strong antiviral effects at a concentration of 10 μM treatment.
體內(nèi)研究： Ebselen (5, 10 mg/kg; IP) decreases 5-HT2 agonist-induced head twitches in a dose-dependent manner. Animal Model: 20-25 g 10-12 week old male C57Bl6 mice Dosage: 5, 10 mg/kg Administration: IP Result: Decreased 5-HT2 agonist-induced head twitches in a dose-dependent manner.
參考文獻： 1. Liang Q, et al. Electrical Stimulation Degenerated Cochlear Synapses Through Oxidative Stress in NeonatalCochlear Explants. Front Neurosci. 2019 Oct 14;13:1073. 2. H Sies, et al. Ebselen, a Selenoorganic Compound as Glutathione Peroxidase Mimic. Free Radic Biol Med. 1993 Mar;14(3):313-23. 3. Jin Z, et al. Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature. 2020 Apr 9. 4. Thenin-Houssier S, et al. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2195-208. 5. Singh N, et al. A safe lithium mimetic for bipolar disorder. Nat Commun. 2013;4:1332. doi: 10.1038/ncomms2320. 6. Hanavan PD, et al. Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines. Oncotarget. 2015 Jul 30;6(21):18418-28.
溶解性： soluble  in  DMSO
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 3.647 ml 18.236 ml 36.472 ml
5 mM 0.729 ml 3.647 ml 7.294 ml
10 mM 0.365 ml 1.824 ml 3.647 ml
50 mM 0.073 ml 0.365 ml 0.729 ml
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參考文獻

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摩爾濃度計算器

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