| 產(chǎn)品描述： | inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties. |
| 靶點： |
STAT3;STAT |
| 體外研究： |
inS3-54A18 (5?μM) reduces wound healing to 64% and 76% for A549 and MDA-MB-231 cells, respectively. inS3-54A18 at 10?μM further reduces the healing to 47% and 39%, respectively. inS3-54A18 inhibits the expression of STAT3 downstream target genes and the binding of STAT3 to its endogenous target sequences. inS3-54A18 does not affect the constitutive or IL-6-induced STAT3 activation (Tyr705 phosphorylation) but represses STAT3 target gene (survivin) expression。 |
| 體內(nèi)研究： |
inS3-54A18 (200?mg/kg, p.o.) inhibits tumor growth, metastasis and expression of STAT3 target genes in a mouse xenograft model of A549 cells。 |
| 參考文獻(xiàn)： |
1. Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92 |
| 溶解性： |
Soluble in DMSO |
| 保存條件： |
-20°C |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.675 ml |
13.375 ml |
26.75 ml |
| 5 mM |
0.535 ml |
2.675 ml |
5.35 ml |
| 10 mM |
0.268 ml |
1.338 ml |
2.675 ml |
| 50 mM |
0.054 ml |
0.268 ml |
0.535 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學(xué)品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京